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1.
Can be used in the place of "fa sho," as in to agree with another, or to give props to somebody for some tight shit
You heard I got that job at Nike?
That's wassup
Por Cheezie 14 de octubre de 2004
 
2.
An term of agreement.
Zan: Yo, I got a 95% in my Event Management Class!
Orande: Oh Word? I got a 95% too!
Both: THAT'S WASSUP!
Por Zans 11 de mayo de 2006
 
3.
Among the same lines as saying, 'okay', 'for sure', 'yeah' or 'awready'. Mostly used down in Texas.

friend #1: "what's going down tonight?..."
friend #2: "we gonna party like rockstars!!"
friend #1: "yo, thats was sup!!"

Joe: "let's get blazed?!?"
Mike: "uhh, thats was up!!"
Por eddy cee 14 de marzo de 2008
 
4.
It means that you agree with something or it also means yes. It also means to ask for head.
Hey Samantha! That's Wassup
Por Orlando Castillo 07 de enero de 2004