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1.
The growth of an inflammed, festered, and bloody hemorrhoid that creates a groove-like affect in your feces.
Dave, don't do it. Jeff has an ass knuckle, that's not going to be fun.
Por Sean Piner 30 de septiembre de 2006
 
2.
Someone who is clueless or stupid.
"Dude the new guy is such a dumbass!

"for real, he's a total friggin' ass-knuckle!
Por Skin bone 21 de mayo de 2011