To piss off, grind the gears of, makes one twitch just thinking about the issue.
It really irks my nerves when someone smacks a random girls ass.

You know what irks my nerves? Going to school, being greeted with the 7th Grade Twilight Fan-girl made posters announcing how soon New Moon is coming out in theaters.
Por My lolwut? 20 de octubre de 2009

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