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A slang phrase referring to nausea of such extreme intensity that the physical act of vomiting "feels" comparable to expelling the contents of your viscera or gray matter (brain).
If you drink too much alcohol, you'll be "puking your brains out" in front of everyone.
Por David in California 23 de octubre de 2006

Words related to puking your brains out

nausea puke puking sick vomiting