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1.
the generic name for a date rape drug
Hey i slipped Anna ruffies this weekend.
Por blackdahlia 19 de febrero de 2004
 
2.
A bocce throw, when the ball is thrown overhand as hard as possible to know the other teams ball away from the palino. The name Ruffe stems from the generic date rape drug name, and with both the date rape drug, and this throw, the main purpose is to knock out the target.
"Go for a Ruffe so they dont score their ninth point and win this round."
Por Bocceman 25 de septiembre de 2009
 
3.
Something someone slips into a girl's drink so he can have sex with her
Peter wants to slip a ruffe into Tara's drink so he can have sex with her.
Por Paul 30 de marzo de 2005