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1.
something you say in parting, a farewell, means "good luck" or "best of luck", "hope things go well"

originates in the graffiti subculture. refers to the hope that one's tag, throw up, piece, or burner will "stay up" and not be buffed.
friend # 1: "Great to see you my brotha, i c u lata. peace"

friend # 2: "aight. stay up!"
Por peace y'all 24 de abril de 2006
 
2.
my favourite definition is,
1# stay up in life. dont let life knock u down u know. smile n stay shine, even if your broke or just got robbed, life is still fine.

2# from the graffitiworld, stay up is like get yo shit out there, get up and dont get x-ed or buffed.

3# simply a good-bye
1# from emcee identitys song stay up:
cuz feelin blue wont help ya, only make u depressed
so stay up i say and dont live life stressed

2# man u gotta get out there, u gotta get up n stay up

3# iight homie, hit ya up tomorrow, stay up
Por hanginlikebatman 10 de mayo de 2006
 
3.
1.Stay on top of yo' game, nigga. 2.don't let "the man" beat you down.
I'm gettin out(of jail)today, stay up, brothaz!!!
Por Mr.Dude 09 de enero de 2004
 
4.
a farewell, means "good luck" or "best of luck", "hope things go well for you!"

originates in the graffiti subculture. refers to the hope that one's tag, throw up or piece will "stay up" and not be buffed.
Great to see you my brotha, stay up!
Por peace y'all 24 de abril de 2006
 
5.
when a group of people are getting high together and people have to leave, you say stay up to each other to stay high.
*after a session*
"yo bro i gotta bounce home"
"alright for sure, stay up"
Por scavenger1 30 de octubre de 2009
 
6.
a hokey inner city "bye-bye"
The fact that "stay up" isn't in the urban dictionary is proof that only geeked out nerds go to this website.
Por adhesives 31 de agosto de 2003
 
7.
Means to keep smoking bud and to keep getting high, hence staying up
Thanks for smokin me out yo, stay up
Por scoresman923 28 de marzo de 2004