1) Major League Soccer, the only professional soccer league in the United States. Founded 1993. See also NFL, MLB, NBA, NHL, and if you're feeling generous, WNBA. There are no other definitions for this acronym in popular use in the United States, at least not by anyone older than 15.
2) My Life Sucks. Typically used by whiny teenagers who don't have internet connections or access to Urban Dictionary, or they would know this was replaced by FML years ago... a term which is not only more common, but has its own website, wiki, Urban Dictionary page, and line of t-shirts.
1) Peter: MLS has 16 teams now.
Paul: I don't care.
2) Jack: Hello, I am your boyfriend Jack. My parents grounded me this weekend. ZOMG MLS WTF LOL.
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